6-HYDROXYINDOLE
6-HYDROXYINDOLE is permitted in cosmetics within the EU subject to the conditions laid down in Regulation (EC) No 1223/2009. Review the restrictions, permitted concentration and Safety Gate alerts.
Regulatory status as of 2026-08-28 (per the CosIng database).
About the ingredient
1H-indol-6-ol
EU regulatory status
Annex of Regulation (EC) No 1223/2009: Annex III/209
Source: the European Commission's official CosIng database and Regulation (EC) No 1223/2009 of the European Parliament and of the Council on cosmetic products. How we assess ingredients — full methodology.
- View the entry in the CosIng database (European Commission)
- Open Regulation 1223/2009 in EUR-Lex
- Check the chemical profile in PubChem
Last updated:
Functions in cosmetics
Frequently asked questions
Is 6-HYDROXYINDOLE safe in cosmetics?
6-HYDROXYINDOLE is permitted in cosmetics in the EU, but subject to the conditions set out in Regulation (EC) No 1223/2009 — typically a maximum concentration, product category or a mandatory warning on the packaging. Manufacturers must comply with these limits.
In which annex of Regulation 1223/2009 is 6-HYDROXYINDOLE listed?
6-HYDROXYINDOLE is listed under reference Annex III/209 in the annexes of Regulation (EC) No 1223/2009 on cosmetic products. The first part (Roman numeral) indicates the annex: II – prohibited substances, III – substances restricted by conditions, IV – permitted colorants, V – permitted preservatives, VI – permitted UV filters.
What functions does 6-HYDROXYINDOLE perform in cosmetics?
According to the European Commission's CosIng database, 6-HYDROXYINDOLE performs the following functions in cosmetics: HAIR DYEING. Functions are defined in the CosIng glossary and describe the technological role of a substance in the finished product.
Are there Safety Gate alerts concerning 6-HYDROXYINDOLE?
Our copy of the EU Safety Gate database currently contains no alerts linking 6-HYDROXYINDOLE to a cosmetic recall. The database is refreshed regularly from the European Commission's official Safety Gate system.