GLYCERYL DIRETINOATE
GLYCERYL DIRETINOATE is banned in cosmetics in the EU — Annex II, entry 375 of Regulation (EC) No 1223/2009. Review the regulatory details and Safety Gate alerts.
Regulatory data checked on 2026-09-05. The legal status follows Regulation (EC) No 1223/2009 and its annexes; the substance is identified from the European Commission's CosIng database.
About the ingredient
Glyceryl Diretinoate is the diester formed by the reaction of Glycerin with Retinoic Acid.
EU regulatory status
Annex of Regulation (EC) No 1223/2009: II/375
Regulatory note: ?
What entry II/375 of the Regulation says
Tretinoin (INN) (retinoic acid and its salts)
Source: the European Commission's official CosIng database and Regulation (EC) No 1223/2009 of the European Parliament and of the Council on cosmetic products. How we assess ingredients — full methodology.
Last updated:
Functions in cosmetics
Frequently asked questions
Is GLYCERYL DIRETINOATE safe in cosmetics?
GLYCERYL DIRETINOATE falls under Annex II to Regulation (EC) No 1223/2009, and under Article 14 a cosmetic product placed on the EU market must not contain a substance prohibited by that annex. This is a legal status, not a toxicity finding about any particular product. Where a non-compliant product is found, the competent authority requires the responsible person to bring it into conformity, withdraw it from the market or recall it, proportionate to the risk; products presenting a serious risk are also notified through the EU Safety Gate.
In which annex of Regulation 1223/2009 does GLYCERYL DIRETINOATE fall?
GLYCERYL DIRETINOATE falls under reference II/375 in the annexes of Regulation (EC) No 1223/2009 on cosmetic products. An annex entry may name a substance directly or cover it as part of a broader category. The first part (Roman numeral) indicates the annex: II – prohibited substances, III – substances restricted by conditions, IV – permitted colorants, V – permitted preservatives, VI – permitted UV filters.
What functions does GLYCERYL DIRETINOATE perform in cosmetics?
According to the European Commission's CosIng database, GLYCERYL DIRETINOATE performs the following functions in cosmetics: SKIN CONDITIONING. Functions are defined in the CosIng glossary and describe the technological role of a substance in the finished product.
Are there Safety Gate alerts concerning GLYCERYL DIRETINOATE?
Our copy of the EU Safety Gate database currently contains no alerts linking GLYCERYL DIRETINOATE to a cosmetic recall. The database is refreshed regularly from the European Commission's official Safety Gate system.