HUMAN FORESKIN FIBROBLAST CELL CONDITIONED MEDIA
HUMAN FORESKIN FIBROBLAST CELL CONDITIONED MEDIA is banned in cosmetics in the EU — Annex II, entry 416 of Regulation (EC) No 1223/2009. Review the regulatory details and Safety Gate alerts.
Regulatory data checked on 2026-09-05. The legal status follows Regulation (EC) No 1223/2009 and its annexes; the substance is identified from the European Commission's CosIng database.
About the ingredient
Human Foreskin Fibroblast Cell Conditioned Media is the growth media removed from cultures of human foreskin fibroblast cells after several days of growth. The starting media is Dulbecco's Modified Eagle Medium, and may or may not contain fetal bovine serum.
EU regulatory status
Annex of Regulation (EC) No 1223/2009: II/416
What entry II/416 of the Regulation says
Cells, tissues or products of human origin
Source: the European Commission's official CosIng database and Regulation (EC) No 1223/2009 of the European Parliament and of the Council on cosmetic products. How we assess ingredients — full methodology.
Last updated:
Functions in cosmetics
Frequently asked questions
Is HUMAN FORESKIN FIBROBLAST CELL CONDITIONED MEDIA safe in cosmetics?
HUMAN FORESKIN FIBROBLAST CELL CONDITIONED MEDIA falls under Annex II to Regulation (EC) No 1223/2009, and under Article 14 a cosmetic product placed on the EU market must not contain a substance prohibited by that annex. This is a legal status, not a toxicity finding about any particular product. Where a non-compliant product is found, the competent authority requires the responsible person to bring it into conformity, withdraw it from the market or recall it, proportionate to the risk; products presenting a serious risk are also notified through the EU Safety Gate.
In which annex of Regulation 1223/2009 does HUMAN FORESKIN FIBROBLAST CELL CONDITIONED MEDIA fall?
HUMAN FORESKIN FIBROBLAST CELL CONDITIONED MEDIA falls under reference II/416 in the annexes of Regulation (EC) No 1223/2009 on cosmetic products. An annex entry may name a substance directly or cover it as part of a broader category. The first part (Roman numeral) indicates the annex: II – prohibited substances, III – substances restricted by conditions, IV – permitted colorants, V – permitted preservatives, VI – permitted UV filters.
What functions does HUMAN FORESKIN FIBROBLAST CELL CONDITIONED MEDIA perform in cosmetics?
According to the European Commission's CosIng database, HUMAN FORESKIN FIBROBLAST CELL CONDITIONED MEDIA performs the following functions in cosmetics: SKIN CONDITIONING. Functions are defined in the CosIng glossary and describe the technological role of a substance in the finished product.
Are there Safety Gate alerts concerning HUMAN FORESKIN FIBROBLAST CELL CONDITIONED MEDIA?
Our copy of the EU Safety Gate database currently contains no alerts linking HUMAN FORESKIN FIBROBLAST CELL CONDITIONED MEDIA to a cosmetic recall. The database is refreshed regularly from the European Commission's official Safety Gate system.