HUMAN MONONUCLEAR CELL CONDITIONED MEDIA EXTRACT
HUMAN MONONUCLEAR CELL CONDITIONED MEDIA EXTRACT is banned in cosmetics in the EU — Annex II, entry 416 of Regulation (EC) No 1223/2009. Review the regulatory details and Safety Gate alerts.
Regulatory status as of 2026-08-28 (per the CosIng database).
About the ingredient
Human Mononuclear Cell Conditioned Media Extract is the extract of the growth media removed from cultures of human mononuclear cells after several days of growth.
EU regulatory status
Annex of Regulation (EC) No 1223/2009: II/416
Source: the European Commission's official CosIng database and Regulation (EC) No 1223/2009 of the European Parliament and of the Council on cosmetic products. How we assess ingredients — full methodology.
Last updated:
Functions in cosmetics
Frequently asked questions
Is HUMAN MONONUCLEAR CELL CONDITIONED MEDIA EXTRACT safe in cosmetics?
HUMAN MONONUCLEAR CELL CONDITIONED MEDIA EXTRACT is banned in the EU under Annex II of Regulation (EC) No 1223/2009 and may not be used in cosmetics placed on the EU market. Cosmetics containing this substance are withdrawn by national inspectorates and reported to the EU Safety Gate database.
In which annex of Regulation 1223/2009 is HUMAN MONONUCLEAR CELL CONDITIONED MEDIA EXTRACT listed?
HUMAN MONONUCLEAR CELL CONDITIONED MEDIA EXTRACT is listed under reference II/416 in the annexes of Regulation (EC) No 1223/2009 on cosmetic products. The first part (Roman numeral) indicates the annex: II – prohibited substances, III – substances restricted by conditions, IV – permitted colorants, V – permitted preservatives, VI – permitted UV filters.
What functions does HUMAN MONONUCLEAR CELL CONDITIONED MEDIA EXTRACT perform in cosmetics?
According to the European Commission's CosIng database, HUMAN MONONUCLEAR CELL CONDITIONED MEDIA EXTRACT performs the following functions in cosmetics: SKIN CONDITIONING. Functions are defined in the CosIng glossary and describe the technological role of a substance in the finished product.
Are there Safety Gate alerts concerning HUMAN MONONUCLEAR CELL CONDITIONED MEDIA EXTRACT?
Our copy of the EU Safety Gate database currently contains no alerts linking HUMAN MONONUCLEAR CELL CONDITIONED MEDIA EXTRACT to a cosmetic recall. The database is refreshed regularly from the European Commission's official Safety Gate system.