IMMORTALIZED HUMAN TOOTH PULP STEM CELL CONDITIONED MEDIA
IMMORTALIZED HUMAN TOOTH PULP STEM CELL CONDITIONED MEDIA is banned in cosmetics in the EU — Annex II, entry 416 of Regulation (EC) No 1223/2009. Review the regulatory details and Safety Gate alerts.
Regulatory status as of 2026-08-28 (per the CosIng database).
About the ingredient
Immortalized Human Tooth Pulp Stem Cell Conditioned Media is the growth media removed from cultures of cells isolated from human tooth pulp tissue after several days of growth. The cells are immortalized by the insertion of the human papillomavirus E6 and E7 genes, and hTERT gene. The starting media is either Dulbecco's Modified Eagle Medium which may or may not contain fetal bovine serum, or a serum-free nutrient media.
EU regulatory status
Annex of Regulation (EC) No 1223/2009: II/416
Source: the European Commission's official CosIng database and Regulation (EC) No 1223/2009 of the European Parliament and of the Council on cosmetic products. How we assess ingredients — full methodology.
Last updated:
Functions in cosmetics
Frequently asked questions
Is IMMORTALIZED HUMAN TOOTH PULP STEM CELL CONDITIONED MEDIA safe in cosmetics?
IMMORTALIZED HUMAN TOOTH PULP STEM CELL CONDITIONED MEDIA is banned in the EU under Annex II of Regulation (EC) No 1223/2009 and may not be used in cosmetics placed on the EU market. Cosmetics containing this substance are withdrawn by national inspectorates and reported to the EU Safety Gate database.
In which annex of Regulation 1223/2009 is IMMORTALIZED HUMAN TOOTH PULP STEM CELL CONDITIONED MEDIA listed?
IMMORTALIZED HUMAN TOOTH PULP STEM CELL CONDITIONED MEDIA is listed under reference II/416 in the annexes of Regulation (EC) No 1223/2009 on cosmetic products. The first part (Roman numeral) indicates the annex: II – prohibited substances, III – substances restricted by conditions, IV – permitted colorants, V – permitted preservatives, VI – permitted UV filters.
What functions does IMMORTALIZED HUMAN TOOTH PULP STEM CELL CONDITIONED MEDIA perform in cosmetics?
According to the European Commission's CosIng database, IMMORTALIZED HUMAN TOOTH PULP STEM CELL CONDITIONED MEDIA performs the following functions in cosmetics: ANTIPLAQUE, HAIR CONDITIONING, HUMECTANT, ORAL CARE. Functions are defined in the CosIng glossary and describe the technological role of a substance in the finished product.
Are there Safety Gate alerts concerning IMMORTALIZED HUMAN TOOTH PULP STEM CELL CONDITIONED MEDIA?
Our copy of the EU Safety Gate database currently contains no alerts linking IMMORTALIZED HUMAN TOOTH PULP STEM CELL CONDITIONED MEDIA to a cosmetic recall. The database is refreshed regularly from the European Commission's official Safety Gate system.