R-(ASPARTYL OLIGOPEPTIDE-162 HEXAPEPTIDE-40 ASPARTYL RH-POLYPEPTIDE-114)/R- (ASPARTYL OLIGOPEPTIDE-162 ASPARTYL RH-POLYPEPTIDE-115)/R-( ASPARTYL OLIGOPEPTIDE-162 ASPARTYL RH-POLYPEPTIDE-48)

Banned in the EU CosIng #97003

R-(ASPARTYL OLIGOPEPTIDE-162 HEXAPEPTIDE-40 ASPARTYL RH-POLYPEPTIDE-114)/R- (ASPARTYL OLIGOPEPTIDE-162 ASPARTYL RH-POLYPEPTIDE-115)/R-( ASPARTYL OLIGOPEPTIDE-162 ASPARTYL RH-POLYPEPTIDE-48) is banned in cosmetics in the EU — Annex II, entry 416 of Regulation (EC) No 1223/2009. Review the regulatory details and Safety Gate alerts.

Regulatory status as of 2026-08-28 (per the CosIng database).

About the ingredient

r-(Aspartyl Oligopeptide-162 Hexapeptide-40 Aspartyl rh-Polypeptide-114)/r-(Aspartyl Oligopeptide-162 Aspartyl rh-Polypeptide-115)/r-( Aspartyl Oligopeptide-162 Aspartyl rh-Polypeptide-48) is the heterotrimeric peptide assembled by the combination of three recombinant fusion peptides: r-(Aspartyl Oligopeptide-162 Hexapeptide-40 Aspartyl rh-Polypeptide-114), r-(Aspartyl Oligopeptide-162 Aspartyl rh-Polypeptide-115), and r-(Aspartyl Oligopeptide-162 Aspartyl rh-Polypeptide-48). The three chains may have inter-chain and/or intra-chain disulfide bonds.

EU regulatory status

Annex of Regulation (EC) No 1223/2009: II/416

Source: the European Commission's official CosIng database and Regulation (EC) No 1223/2009 of the European Parliament and of the Council on cosmetic products. How we assess ingredients — full methodology.

Last updated:

Functions in cosmetics

Frequently asked questions

  • Is R-(ASPARTYL OLIGOPEPTIDE-162 HEXAPEPTIDE-40 ASPARTYL RH-POLYPEPTIDE-114)/R- (ASPARTYL OLIGOPEPTIDE-162 ASPARTYL RH-POLYPEPTIDE-115)/R-( ASPARTYL OLIGOPEPTIDE-162 ASPARTYL RH-POLYPEPTIDE-48) safe in cosmetics?

    R-(ASPARTYL OLIGOPEPTIDE-162 HEXAPEPTIDE-40 ASPARTYL RH-POLYPEPTIDE-114)/R- (ASPARTYL OLIGOPEPTIDE-162 ASPARTYL RH-POLYPEPTIDE-115)/R-( ASPARTYL OLIGOPEPTIDE-162 ASPARTYL RH-POLYPEPTIDE-48) is banned in the EU under Annex II of Regulation (EC) No 1223/2009 and may not be used in cosmetics placed on the EU market. Cosmetics containing this substance are withdrawn by national inspectorates and reported to the EU Safety Gate database.

  • In which annex of Regulation 1223/2009 is R-(ASPARTYL OLIGOPEPTIDE-162 HEXAPEPTIDE-40 ASPARTYL RH-POLYPEPTIDE-114)/R- (ASPARTYL OLIGOPEPTIDE-162 ASPARTYL RH-POLYPEPTIDE-115)/R-( ASPARTYL OLIGOPEPTIDE-162 ASPARTYL RH-POLYPEPTIDE-48) listed?

    R-(ASPARTYL OLIGOPEPTIDE-162 HEXAPEPTIDE-40 ASPARTYL RH-POLYPEPTIDE-114)/R- (ASPARTYL OLIGOPEPTIDE-162 ASPARTYL RH-POLYPEPTIDE-115)/R-( ASPARTYL OLIGOPEPTIDE-162 ASPARTYL RH-POLYPEPTIDE-48) is listed under reference II/416 in the annexes of Regulation (EC) No 1223/2009 on cosmetic products. The first part (Roman numeral) indicates the annex: II – prohibited substances, III – substances restricted by conditions, IV – permitted colorants, V – permitted preservatives, VI – permitted UV filters.

  • What functions does R-(ASPARTYL OLIGOPEPTIDE-162 HEXAPEPTIDE-40 ASPARTYL RH-POLYPEPTIDE-114)/R- (ASPARTYL OLIGOPEPTIDE-162 ASPARTYL RH-POLYPEPTIDE-115)/R-( ASPARTYL OLIGOPEPTIDE-162 ASPARTYL RH-POLYPEPTIDE-48) perform in cosmetics?

    According to the European Commission's CosIng database, R-(ASPARTYL OLIGOPEPTIDE-162 HEXAPEPTIDE-40 ASPARTYL RH-POLYPEPTIDE-114)/R- (ASPARTYL OLIGOPEPTIDE-162 ASPARTYL RH-POLYPEPTIDE-115)/R-( ASPARTYL OLIGOPEPTIDE-162 ASPARTYL RH-POLYPEPTIDE-48) performs the following functions in cosmetics: NOT REPORTED. Functions are defined in the CosIng glossary and describe the technological role of a substance in the finished product.

  • Are there Safety Gate alerts concerning R-(ASPARTYL OLIGOPEPTIDE-162 HEXAPEPTIDE-40 ASPARTYL RH-POLYPEPTIDE-114)/R- (ASPARTYL OLIGOPEPTIDE-162 ASPARTYL RH-POLYPEPTIDE-115)/R-( ASPARTYL OLIGOPEPTIDE-162 ASPARTYL RH-POLYPEPTIDE-48)?

    Our copy of the EU Safety Gate database currently contains no alerts linking R-(ASPARTYL OLIGOPEPTIDE-162 HEXAPEPTIDE-40 ASPARTYL RH-POLYPEPTIDE-114)/R- (ASPARTYL OLIGOPEPTIDE-162 ASPARTYL RH-POLYPEPTIDE-115)/R-( ASPARTYL OLIGOPEPTIDE-162 ASPARTYL RH-POLYPEPTIDE-48) to a cosmetic recall. The database is refreshed regularly from the European Commission's official Safety Gate system.

Related ingredients

Other substances with a similar function in cosmetics, grouped under the same provision of Regulation 1223/2009.

Related blog articles

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