RH-POLYPEPTIDE-104
RH-POLYPEPTIDE-104 is banned in cosmetics in the EU — Annex II, entry 416 of Regulation (EC) No 1223/2009. Review the regulatory details and Safety Gate alerts.
Regulatory status as of 2026-08-28 (per the CosIng database).
About the ingredient
Zn-alpha-2-GP
EU regulatory status
Annex of Regulation (EC) No 1223/2009: II/416
Source: the European Commission's official CosIng database and Regulation (EC) No 1223/2009 of the European Parliament and of the Council on cosmetic products. How we assess ingredients — full methodology.
Last updated:
Functions in cosmetics
Frequently asked questions
Is RH-POLYPEPTIDE-104 safe in cosmetics?
RH-POLYPEPTIDE-104 is banned in the EU under Annex II of Regulation (EC) No 1223/2009 and may not be used in cosmetics placed on the EU market. Cosmetics containing this substance are withdrawn by national inspectorates and reported to the EU Safety Gate database.
In which annex of Regulation 1223/2009 is RH-POLYPEPTIDE-104 listed?
RH-POLYPEPTIDE-104 is listed under reference II/416 in the annexes of Regulation (EC) No 1223/2009 on cosmetic products. The first part (Roman numeral) indicates the annex: II – prohibited substances, III – substances restricted by conditions, IV – permitted colorants, V – permitted preservatives, VI – permitted UV filters.
What functions does RH-POLYPEPTIDE-104 perform in cosmetics?
According to the European Commission's CosIng database, RH-POLYPEPTIDE-104 performs the following functions in cosmetics: SKIN PROTECTING. Functions are defined in the CosIng glossary and describe the technological role of a substance in the finished product.
Are there Safety Gate alerts concerning RH-POLYPEPTIDE-104?
Our copy of the EU Safety Gate database currently contains no alerts linking RH-POLYPEPTIDE-104 to a cosmetic recall. The database is refreshed regularly from the European Commission's official Safety Gate system.