RH-POLYPEPTIDE-11 DIPEPTIDE-19 OLIGOPEPTIDE-91 HEXAPEPTIDE-40
RH-POLYPEPTIDE-11 DIPEPTIDE-19 OLIGOPEPTIDE-91 HEXAPEPTIDE-40 is banned in cosmetics in the EU — Annex II, entry 416 of Regulation (EC) No 1223/2009. Review the regulatory details and Safety Gate alerts.
Regulatory status as of 2026-08-28 (per the CosIng database).
About the ingredient
rh-Polypeptide-11 Dipeptide-19 Oligopeptide-91 Hexapeptide-40 is a single chain synthetic fusion peptide, produced by fermentation in E. coli. The starting gene is synthesized by the fusion of the gene from rh-Polypeptide-11, Dipeptide-19, Oligopeptide-91 and Hexapeptide-40. The fused peptide contains 184 amino acids and consists of the proper sequence of the 20 standard amino acids.
EU regulatory status
Annex of Regulation (EC) No 1223/2009: II/416
Source: the European Commission's official CosIng database and Regulation (EC) No 1223/2009 of the European Parliament and of the Council on cosmetic products. How we assess ingredients — full methodology.
Last updated:
Functions in cosmetics
Frequently asked questions
Is RH-POLYPEPTIDE-11 DIPEPTIDE-19 OLIGOPEPTIDE-91 HEXAPEPTIDE-40 safe in cosmetics?
RH-POLYPEPTIDE-11 DIPEPTIDE-19 OLIGOPEPTIDE-91 HEXAPEPTIDE-40 is banned in the EU under Annex II of Regulation (EC) No 1223/2009 and may not be used in cosmetics placed on the EU market. Cosmetics containing this substance are withdrawn by national inspectorates and reported to the EU Safety Gate database.
In which annex of Regulation 1223/2009 is RH-POLYPEPTIDE-11 DIPEPTIDE-19 OLIGOPEPTIDE-91 HEXAPEPTIDE-40 listed?
RH-POLYPEPTIDE-11 DIPEPTIDE-19 OLIGOPEPTIDE-91 HEXAPEPTIDE-40 is listed under reference II/416 in the annexes of Regulation (EC) No 1223/2009 on cosmetic products. The first part (Roman numeral) indicates the annex: II – prohibited substances, III – substances restricted by conditions, IV – permitted colorants, V – permitted preservatives, VI – permitted UV filters.
What functions does RH-POLYPEPTIDE-11 DIPEPTIDE-19 OLIGOPEPTIDE-91 HEXAPEPTIDE-40 perform in cosmetics?
According to the European Commission's CosIng database, RH-POLYPEPTIDE-11 DIPEPTIDE-19 OLIGOPEPTIDE-91 HEXAPEPTIDE-40 performs the following functions in cosmetics: HAIR CONDITIONING, SKIN CONDITIONING, SKIN PROTECTING. Functions are defined in the CosIng glossary and describe the technological role of a substance in the finished product.
Are there Safety Gate alerts concerning RH-POLYPEPTIDE-11 DIPEPTIDE-19 OLIGOPEPTIDE-91 HEXAPEPTIDE-40?
Our copy of the EU Safety Gate database currently contains no alerts linking RH-POLYPEPTIDE-11 DIPEPTIDE-19 OLIGOPEPTIDE-91 HEXAPEPTIDE-40 to a cosmetic recall. The database is refreshed regularly from the European Commission's official Safety Gate system.