SPIRONOLACTONE
SPIRONOLACTONE is banned in cosmetics in the EU — Annex II, entry 4 of Regulation (EC) No 1223/2009. Review the regulatory details and Safety Gate alerts.
Regulatory data checked on 2026-09-05. The legal status follows Regulation (EC) No 1223/2009 and its annexes; the substance is identified from the European Commission's CosIng database.
About the ingredient
17-alpha-Pregn-4-ene-21-carboxylic acid, 17-hydroxy-7-alpha-mercapto- 3-oxo-, gamma-lactone acetate
EU regulatory status
Annex of Regulation (EC) No 1223/2009: II/4
What entry II/4 of the Regulation says
Spironolactone (INN)
Source: the European Commission's official CosIng database and Regulation (EC) No 1223/2009 of the European Parliament and of the Council on cosmetic products. How we assess ingredients — full methodology.
- View the entry in the CosIng database (European Commission)
- Open Regulation 1223/2009 in EUR-Lex
- Check the chemical profile in PubChem
Last updated:
Functions in cosmetics
Frequently asked questions
Is SPIRONOLACTONE safe in cosmetics?
SPIRONOLACTONE falls under Annex II to Regulation (EC) No 1223/2009, and under Article 14 a cosmetic product placed on the EU market must not contain a substance prohibited by that annex. This is a legal status, not a toxicity finding about any particular product. Where a non-compliant product is found, the competent authority requires the responsible person to bring it into conformity, withdraw it from the market or recall it, proportionate to the risk; products presenting a serious risk are also notified through the EU Safety Gate.
In which annex of Regulation 1223/2009 does SPIRONOLACTONE fall?
SPIRONOLACTONE falls under reference II/4 in the annexes of Regulation (EC) No 1223/2009 on cosmetic products. An annex entry may name a substance directly or cover it as part of a broader category. The first part (Roman numeral) indicates the annex: II – prohibited substances, III – substances restricted by conditions, IV – permitted colorants, V – permitted preservatives, VI – permitted UV filters.
What functions does SPIRONOLACTONE perform in cosmetics?
According to the European Commission's CosIng database, SPIRONOLACTONE performs the following functions in cosmetics: NOT REPORTED. Functions are defined in the CosIng glossary and describe the technological role of a substance in the finished product.
Are there Safety Gate alerts concerning SPIRONOLACTONE?
Our copy of the EU Safety Gate database currently contains no alerts linking SPIRONOLACTONE to a cosmetic recall. The database is refreshed regularly from the European Commission's official Safety Gate system.