SPLEEN HYDROLYSATE
SPLEEN HYDROLYSATE is banned in cosmetics in the EU — Annex II, entry 419 of Regulation (EC) No 1223/2009. Review the regulatory details and Safety Gate alerts.
Regulatory data checked on 2026-09-05. The legal status follows Regulation (EC) No 1223/2009 and its annexes; the substance is identified from the European Commission's CosIng database.
About the ingredient
Protein hydrolyzates, spleen. Substance obtained by acidic, alkaline, or enzymatic hydrolysis of animal spleen composed primarily of amino acids, peptides, and proteins. It may contain impurities consisting chiefly of carbohydrates and lipids along with smaller quantities of miscellaneous organic substances of biological origin
EU regulatory status
Annex of Regulation (EC) No 1223/2009: II/419
What entry II/419 of the Regulation says
Category 1 material and Category 2 material as defined in Articles 4 and 5 respectively of Regulation (EC) No 1774/2002 of the European Parliament and of the Council (3), and ingredients derived therefrom
Source: the European Commission's official CosIng database and Regulation (EC) No 1223/2009 of the European Parliament and of the Council on cosmetic products. How we assess ingredients — full methodology.
- View the entry in the CosIng database (European Commission)
- Open Regulation 1223/2009 in EUR-Lex
- Check the chemical profile in PubChem
Last updated:
Functions in cosmetics
Frequently asked questions
Is SPLEEN HYDROLYSATE safe in cosmetics?
SPLEEN HYDROLYSATE falls under Annex II to Regulation (EC) No 1223/2009, and under Article 14 a cosmetic product placed on the EU market must not contain a substance prohibited by that annex. This is a legal status, not a toxicity finding about any particular product. Where a non-compliant product is found, the competent authority requires the responsible person to bring it into conformity, withdraw it from the market or recall it, proportionate to the risk; products presenting a serious risk are also notified through the EU Safety Gate.
In which annex of Regulation 1223/2009 does SPLEEN HYDROLYSATE fall?
SPLEEN HYDROLYSATE falls under reference II/419 in the annexes of Regulation (EC) No 1223/2009 on cosmetic products. An annex entry may name a substance directly or cover it as part of a broader category. The first part (Roman numeral) indicates the annex: II – prohibited substances, III – substances restricted by conditions, IV – permitted colorants, V – permitted preservatives, VI – permitted UV filters.
What functions does SPLEEN HYDROLYSATE perform in cosmetics?
According to the European Commission's CosIng database, SPLEEN HYDROLYSATE performs the following functions in cosmetics: SKIN CONDITIONING. Functions are defined in the CosIng glossary and describe the technological role of a substance in the finished product.
Are there Safety Gate alerts concerning SPLEEN HYDROLYSATE?
Our copy of the EU Safety Gate database currently contains no alerts linking SPLEEN HYDROLYSATE to a cosmetic recall. The database is refreshed regularly from the European Commission's official Safety Gate system.