TRANSGENIC RICE RH-OLIGOPEPTIDE-2
TRANSGENIC RICE RH-OLIGOPEPTIDE-2 is banned in cosmetics in the EU — Annex II, entry 416 of Regulation (EC) No 1223/2009. Review the regulatory details and Safety Gate alerts.
Regulatory status as of 2026-08-28 (per the CosIng database).
About the ingredient
Transgenic Rice rh-Oligopeptide-2 is a single chain recombinant human peptide, produced by rice after insertion of a copy of a human gene into its DNA. The starting gene is directly isolated from a human cell which codes for Insulin-Like Growth Factor 1. It contains a maximum of 195 amino acids, which may contain disulfide bonds and/or glycosylation. The protein consists of the proper sequence of the 20 standard amino acids.
EU regulatory status
Annex of Regulation (EC) No 1223/2009: II/416
Source: the European Commission's official CosIng database and Regulation (EC) No 1223/2009 of the European Parliament and of the Council on cosmetic products. How we assess ingredients — full methodology.
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Functions in cosmetics
Frequently asked questions
Is TRANSGENIC RICE RH-OLIGOPEPTIDE-2 safe in cosmetics?
TRANSGENIC RICE RH-OLIGOPEPTIDE-2 is banned in the EU under Annex II of Regulation (EC) No 1223/2009 and may not be used in cosmetics placed on the EU market. Cosmetics containing this substance are withdrawn by national inspectorates and reported to the EU Safety Gate database.
In which annex of Regulation 1223/2009 is TRANSGENIC RICE RH-OLIGOPEPTIDE-2 listed?
TRANSGENIC RICE RH-OLIGOPEPTIDE-2 is listed under reference II/416 in the annexes of Regulation (EC) No 1223/2009 on cosmetic products. The first part (Roman numeral) indicates the annex: II – prohibited substances, III – substances restricted by conditions, IV – permitted colorants, V – permitted preservatives, VI – permitted UV filters.
What functions does TRANSGENIC RICE RH-OLIGOPEPTIDE-2 perform in cosmetics?
According to the European Commission's CosIng database, TRANSGENIC RICE RH-OLIGOPEPTIDE-2 performs the following functions in cosmetics: SKIN CONDITIONING. Functions are defined in the CosIng glossary and describe the technological role of a substance in the finished product.
Are there Safety Gate alerts concerning TRANSGENIC RICE RH-OLIGOPEPTIDE-2?
Our copy of the EU Safety Gate database currently contains no alerts linking TRANSGENIC RICE RH-OLIGOPEPTIDE-2 to a cosmetic recall. The database is refreshed regularly from the European Commission's official Safety Gate system.