ZINC S-ALLOFERON-1
ZINC S-ALLOFERON-1 is permitted in cosmetics in the EU with restrictions — Annex III, entry 24 of Regulation (EC) No 1223/2009. Review the conditions of use, permitted concentration and Safety Gate alerts.
Regulatory status as of 2026-08-28 (per the CosIng database).
About the ingredient
Zinc s-Alloferon-1 is the zinc salt of a single chain protein produced synthetically to be identical to Alloferon-1 which is found in the blue blowfly, Calliphora vicina. The protein contains 13 amino acids which may contain disulfide bonds and/or glycosylation, and consists of the proper sequence of the 20 standard amino acids.
EU regulatory status
Annex of Regulation (EC) No 1223/2009: III/24
Source: the European Commission's official CosIng database and Regulation (EC) No 1223/2009 of the European Parliament and of the Council on cosmetic products. How we assess ingredients — full methodology.
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Functions in cosmetics
Frequently asked questions
Is ZINC S-ALLOFERON-1 safe in cosmetics?
ZINC S-ALLOFERON-1 is permitted in cosmetics in the EU, but subject to the conditions set out in Regulation (EC) No 1223/2009 — typically a maximum concentration, product category or a mandatory warning on the packaging. Manufacturers must comply with these limits.
In which annex of Regulation 1223/2009 is ZINC S-ALLOFERON-1 listed?
ZINC S-ALLOFERON-1 is listed under reference III/24 in the annexes of Regulation (EC) No 1223/2009 on cosmetic products. The first part (Roman numeral) indicates the annex: II – prohibited substances, III – substances restricted by conditions, IV – permitted colorants, V – permitted preservatives, VI – permitted UV filters.
What functions does ZINC S-ALLOFERON-1 perform in cosmetics?
According to the European Commission's CosIng database, ZINC S-ALLOFERON-1 performs the following functions in cosmetics: SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SKIN PROTECTING. Functions are defined in the CosIng glossary and describe the technological role of a substance in the finished product.
Are there Safety Gate alerts concerning ZINC S-ALLOFERON-1?
Our copy of the EU Safety Gate database currently contains no alerts linking ZINC S-ALLOFERON-1 to a cosmetic recall. The database is refreshed regularly from the European Commission's official Safety Gate system.